The interferon regulatory factor (IRF) family of transcription factors, pivotal for initiating antiviral type I interferon ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

Across all domains of life, immune defenses foil invading viruses by making it impossible for the viruses to replicate. Most ...

Abstract: The classification of DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs) is essential for understanding molecular interactions and regulatory functions. However, the existing ...

New Houston Methodist research has revealed that a protein associated with neurodegenerative diseases such as dementia and amyotrophic lateral sclerosis (ALS) also plays a role in regulating DNA ...

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells. How genes are turned on ...

Transcription Factors (TFs) are pivotal regulators of gene expression and have been implicated in a variety of diseases, including cancer, neurological disorders, autoimmune conditions, and metabolic ...

ABSTRACT: Prostate cancer is reported to be the second most common cancer in men. At this time, there exist over 20 FDA-approved drugs for the treatment of prostate cancer. These include alkylating ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The zinc finger (ZnF) motif is one of the most common nucleic acid binding motifs in ...

This valuable work presents an interpretable protein-DNA Energy Associative (IDEA) model for predicting binding sites and affinities of DNA-binding proteins. While the method is convincing, it ...