When light falls on the eye of a fly, ripples of messages flow through its cells. These messages are carried by molecular messengers forming an intricate information system that exists not just in the ...

PIP2 is an important phosphoinositide that is present in around 1% of the plasma membrane. It is also involved in signal transduction of intracellular and extracellular components. There are two ...

The November 2009 issue of the Journal of General Physiology (JGP) contains two papers by the Rittenhouse laboratory that describe novel findings on how N-type voltage-gated calcium channel (VGCC) ...

Perhaps no topic is hotter in Alzheimer disease molecular research today than the synaptic effects of amyloid-β (Aβ) oligomers. These toxic assemblies disrupt synaptic function, and are leading ...

The regeneration of a signaling molecule, phosphatidylinositol 4,5 bisphosphate (PIP2), is not as simple as it was thought to be. Experimental work and mathematical modelling show that the decades-old ...