But p53 can be deleted during transcription or mutated by missense mutations. When mutated, it expresses deleterious proteins that spur tumorigenesis, and researchers have assumed these mutations are ...
Researchers created a new kind of cancer drug that can grab a mutant protein while also carrying a second hit against the ...
A new study has, for the first time, settled the debate about how a mutated protein present in half of all human cancers drives tumor growth. The discovery will not only facilitate a rethink of the ...
This study is led by Prof. Mingyu Chen (Sir Run-Run Shaw Hospital, Zhejiang University), Prof. Xiujun Cai (Sir Run-Run Shaw Hospital, Zhejiang University), Prof. Jicheng Yu (College of Pharmaceutical ...
The p53 protein — a protein that controls cell division and plays a key role in the prevention of tumor growth — is the most commonly mutated protein across all cancer types, found in more than half ...
Aileron is developing ALRN-6924 to protect patients with p53 mutated cancers against chemotherapy-induced bone marrow toxicities and other toxicities Trial is evaluating ALRN-6924 as a treatment to ...
Patients on ALRN-6924 were able to stay on treatment longer, completing more of the first 4 cycles of carboplatin/pemetrexed (93% of cycles on ALRN-6924 versus 78% on ...
Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown ...
mRNA injections could reduce aggressive ovarian tumors by rescuing an often mutated gene in high-grade serous ovarian patients, according to a preclinical study. The most common form of ovarian cancer ...
Researchers have solved a mystery about the most important driver of cancer development - a mutant protein found in half of all cancers - and how it contributes to tumor growth. Researchers from WEHI ...
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