Numerous recent studies have described cancer-associated hypermethylation in CpG-rich 5′ gene regions (Baylin and Herman, 2000; Issa, 2000). However, net decreases in DNA methylation in cancer often ...

In our analysis of precancerous, hyperplastic breast tumors, 3/8 (38%) of atypical hyperplasias (AH) showed evidence of hypermethylation. None of the five hyperplasias without atypia (NH) showed ...

Transitional cell carcinoma (TCC) is a pan-urothelial disease characterized by multiplicity. Although little is known about the molecular events in upper-tract TCC, similar carcinogenic mechanisms are ...