SOFIE Biosciences, an established U.S. manufacturer and developer of radiopharmaceuticals, today announced that the first patient has been dosed in one of its two Phase 3 clinical trials evaluating ...

The novel radiotracer ¹⁸F-FAPI-RGD in PET/CT scans shows potential for diagnosing ILD in connective tissue disease patients by highlighting fibroblast activation and tissue remodeling. Patients with ...

Figure 1. Maximum-intensity projections and fusion images of [68 Ga]Ga-FAPI PET/CT from representative patients of different NICM subtypes. PET scans were classified into three columns, including ...

Blood tests, ultrasounds, and MRIs often fail to detect the earliest changes in cardiomyopathy, when fibroblasts activate and start the scarring process. Since early detection is crucial for the best ...

This article is based on a poster originally authored by Fiona Leslie, Chloe Whiting, and Megan Webster. TGF-β1-mediated activation of fibroblasts, their transition to α-SMA-expressing myofibroblasts, ...

Renal fibrosis represents a key driver of the pathology of chronic kidney disease (CKD), marked by fibroblast activation, tubular damage and inflammation. Previous work found that cyclic guanosine ...

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates - only 10% after five years. One of the factors contributing to its aggressiveness is its tumor ...

A new PET/CT imaging technique that visualizes activated fibroblasts in the heart muscle enables early detection of multiple forms of cardiomyopathy, according to research presented at the Society of ...

A new PET/CT imaging technique that visualizes activated fibroblasts in the heart muscle enables early detection of multiple forms of cardiomyopathy, according to research presented at the Society of ...