In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that combined inhibition of cell-surface-based and endosomal pathways completely blocked severe acute respiratory ...

A recent study posted to the bioRxiv* preprint server assessed the role of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron spike H655Y mutation on viral entry pathways. Study: ...

Plasma membrane proteins are synthesized in the endoplasmic reticulum (ER), transported through the Golgi/TGN, and delivered to the plasma membrane. At the plasma membrane, some proteins (e.g., ...

The hydrolysis of endosomal PI(4,5)P2 in the intestine of C. elegans is mediated by RAB-10, a mechanism vital for the establishment of immunity against pathogens. Endosomes manage key metabolic ...

A new study offers up yet more evidence that the endosome may be ground zero for Alzheimer’s disease pathogenesis. In Proceedings of the National Academy of Sciences on January 18, scientists led by ...

This is a preview. Log in through your library . Abstract Acidification of the endosomal pathway is important for ligand and receptor sorting, toxin activation, and protein degradation by lysosomal ...

We suggest endosomal Na/H exchangers (eNHE) as a potential target of metformin action. The eNHEs mostly exist in recycling endosomes and late endosomes to control the pH of these organelles. Metformin ...

Mitochondria are structures within cells that convert the energy from food into a form that cells can use. Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a ...

This is a preview. Log in through your library . Abstract Multiple flowering pathways in Arabidopsis (Arabidopsis thaliana) converge on the transcriptional regulation of FLOWERING LOCUS T (FT), ...