Deescalated nab-paclitaxel plus carboplatin showed higher efficacy than nab-paclitaxel plus gemcitabine in early-stage TNBC patients. BRCA1/2 mutation carriers exhibited a more pronounced pathologic ...

Of the 319 patients submitted to genetic testing, 29.8% were carriers of BRCA1/2 mutation, 75.8% at BRCA1 and 24.2% at BRCA2 gene. Of the 21 BRCA1 mutations, the variant c.5266dupC was the most ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women. According to a July 25 JAMA ...

In women with BRCA1 mutations, hormonal contraceptives were associated with a significantly higher risk for breast cancer in a dose-response relationship, researchers reported in an observational ...

Feb. 28 -- FRIDAY, Feb. 27 (HealthDay News) -- Men who are part of families in which some members have BRCA1 or 2 gene mutations -- which boost the risk for breast and ovarian cancer -- typically ...

Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more likely ...

Men with BRCA1 and BRCA2 gene mutations should be given annual prostate cancer screening checks, leading scientists have said. Experts at the Institute of Cancer Research (ICR) in London said men with ...

Risk assessments for cancers related to BRCA mutations could save lives. Annually, about 247,200 cases of breast cancer are diagnosed in the U.S. and nearly 42,000 people die each year from breast ...

They are genes commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...